• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Polymer hydrogels adapted for use as soft contact lenses are treated to provide at least on the surfaces thereof a modified, less hydrophilic polymeric structure inhibiting penetration by bacteria and proteins, whereby development of clouding and discoloration of the lens material is significantly retarded.
    公开号:SU1053761A3
    申请号:SU772468104
    申请日:1977-04-06
    公开日:1983-11-07
    发明作者:Льюис Сиглафф Чарльз；Джозеф Хора Чарльз；П. Тифенбах Джозеф
    申请人:Даймонд Шамрок Корпорейшн (Фирма)；
    IPC主号:
    专利说明:

    SP
    with
    -four
    O5 The invention relates to modified contact lenses based on a copolymer, in particular to a method for producing modified contact lenses based on a copolymer of hydroxyethyl ether of methacrylic acid and ethylene glycol cymethacrylate. The closest in technical essence and the achieved result to the proposed is a method of obtaining moaifed contact lenses based on a copolymer of complex ethoxylated methacrylic acid ester and ethylene glycol cymethacrylate by treating the lenses with a modifying agent at 20-90 ° C with ethyleneimine Cl 1 The disadvantage of this method is unsatisfactory the stability of the lenses to. discoloration and blur. The aim of the invention is to increase the resistance of lenses to discoloration and misting. The goal is achieved by the fact that according to the method of obtaining modified contact lenses based on a copolymer of oxethylated ester of methacrylic acid and ethylene glycol dimex acrylate by treating the lipses with a modifying agent at 20% E0, a compound selected from a group including aliphatic Co is used as a modifying agent -, -amino-alcohol and C, C.-alkanyiol, and the treatment is carried out for 5-180 minutes, Example 1. Contact lenses based on a copolymer of ethoxylated methacrylic acid and ethylene glycol dimethacrylate (95: 5) are cut into 1.27 cm specimens. I am fed into it a bone containing 50 ml of ethylenediamine (test a), or propane diamine (test b), or hexanediamine (test c), or 1,10 diamino-aacane (test d), or 1.12-aamino-dinododecane (test e), or 2-aminoethanol (test e), or 4-amino-1-butanol (test g), or b-amino- 1-hexa-. nola (experiment 3), or propandithiol (experiment and), or butandithiol (experiment k), or ethyleneimine (experiment l, known). Samples are left in the vessel at 60 ° C for 120 minutes. Then the samples are removed from the tank and washed with distilled water for 30 minutes. They are fed for 15 hours into a 1% solution of sodium chloride in distilled water and then stelyzed by boiling for 20 minutes in a 1% solution of sodium chloride in distilled water. . The resistance to discoloration and misting of the contact lenses so treated is determined as follows. Samples are stored in a fresh artificial solution of human tears, which contains 1.0% sodium chloride, 0.06% lizozyme, 0.06% albumin, 0.04% urea, 0.04% ug globulin, O , 04% oC globulin and 0.004% glucose. Each day, the samples are removed from the solution, cleaned in a commercial solution for cleaning contact lenses, and sterilized by boiling in 1% -41% sodium chloride solution for 20 minutes. After 15 days, the samples are immersed for two minutes in the resorcinzine phthalcine dye radioactively labeled, after which they are washed with distilled water and fed to a scintillation fluid in order to determine the content of the labeled dye by counting disintegrations per minute. Moreover, the greater the number of decays, the higher the content of the marcHpojsaHHOro dye and thus less resistance of contact lenses to the penetration of various substances that cause discoloration and fogging. The results of the experiment are summarized in the table. control
    Table continuation
    Average of three identical
    samples. The images passed all the specified stations,
    except treatment with nitrogen containing
    an agent. Repetition of experience l with the difference
    that ethyleneimine processing is entrapped in
    for 12 hours
    Example 2 Example 1 is repeated with the difference that the treatment with ethylenediamine is carried out at 2 ° C for 180 minutes. When this is calculated 850 disintegrations per minute.
    Example 3 Example 1 is repeated, with the difference that the ethylenedumum was treated at 90 ° C for 5 minutes. In this case, 745 disintegrations per minute are counted.
    Example 4 Example 1 is repeated, with the difference that ethylenediamine treatment is carried out at 80 ° C for 20 minutes. In this case, 738 disintegrations per minute are counted. I
    Thus, the invention allows to obtain contact lenses with increased resistance to discoloration and misting.
    权利要求:
    Claims (1)
    [1]
    METHOD FOR PRODUCING MODIFIED CONTACT LENSES based on a copolymer of ethoxylated ester of methacrylic acid and ethylene glycol demethacrylate by treating the lenses with a modifying agent at 20-9 ° C, characterized in that, in order to increase the resistance of lenses to discoloration and fogging quality the agent, a compound selected from the group consisting of aliphatic C2 ~ C ^ 2-diamine, C ^ -C ^ -alcohol and C ^ -C ^ -alkanedithiol is used, and the treatment is carried out for 5-180 minutes.
    ί
    类似技术:
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    SU1053761A3|1983-11-07|Method for making modified contact lenses
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    同族专利:
    公开号 | 公开日
    IL51835D0|1977-06-30|
    JPS5724892B2|1982-05-26|
    AT351297B|1979-07-10|
    YU39282B|1984-10-31|
    FR2347403B1|1981-08-28|
    ZA772063B|1978-05-30|
    US4128318A|1978-12-05|
    CA1097859A|1981-03-24|
    MX144328A|1981-09-29|
    ATA232477A|1978-12-15|
    CH620773A5|1980-12-15|
    US4097657A|1978-06-27|
    IL51835A|1979-11-30|
    DE2715514A1|1977-10-20|
    AR222961A1|1981-07-15|
    AU512324B2|1980-10-02|
    FR2347403A1|1977-11-04|
    NO771245L|1977-10-10|
    BE853294A|1977-10-06|
    IT1080038B|1985-05-16|
    SE7704028L|1977-10-08|
    DD130380A5|1978-03-22|
    GB1543535A|1979-04-04|
    BR7702164A|1977-12-20|
    YU91377A|1983-01-21|
    DK157377A|1977-10-08|
    NO149096C|1984-02-15|
    NL7703730A|1977-10-11|
    PL108215B1|1980-03-31|
    JPS52123640A|1977-10-18|
    NO149096B|1983-11-07|
    AU2398677A|1978-10-12|
    CS216245B2|1982-10-29|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US3471460A|1961-08-31|1969-10-07|Du Pont|Amine-modified hydrocarbon polymers|
    US3528958A|1967-03-16|1970-09-15|Sinclair Koppers Co|Modified olefin polymers of improved properties|
    US3951528A|1971-06-02|1976-04-20|Patent Structures, Inc.|Method of making polymeric contact lens|
    US3880818A|1972-01-03|1975-04-29|Mitchel Shen|Physiologically compatible plastic contact lenses and a method for their production|
    US3957740A|1972-04-24|1976-05-18|Hydrophilics International, Inc.|Copolymers|
    US3769261A|1972-05-08|1973-10-30|Gulf Research Development Co|Method of preparing stable copolymers of ethylene and at least one ethylenically unsaturated carboxylic acid and the product obtained thereby|US4163609A|1978-10-10|1979-08-07|Neefe Charles W|Self cleaning contact lens|
    US4338419A|1979-02-09|1982-07-06|SyntexInc.|Process for treatment of hydrogel lens with thiols|
    US4312575A|1979-09-18|1982-01-26|Peyman Gholam A|Soft corneal contact lens with tightly cross-linked polymer coating and method of making same|
    US4379893A|1981-08-26|1983-04-12|Diamond Shamrock Corporation|Surface-treated soft contact lenses|
    US4546123A|1984-12-28|1985-10-08|Alcon Laboratories, Inc.|Polymer hydrogels adapted for use as soft contact lenses, and method of preparing same|
    US4569858A|1985-01-28|1986-02-11|Barnes-Hind, Inc.|Surface modification of hydrophilic contact lenses|
    US4687816A|1985-08-14|1987-08-18|Sola U.S.A. Inc.|Surface treatment of soft contact lenses|
    US4734475A|1986-12-15|1988-03-29|Ciba-Geigy Corporation|Wettable surface modified contact lens fabricated from an oxirane containing hydrophobic polymer|
    CS267858B1|1987-01-12|1990-02-12|Sulc Jiri|Contact,if need be,intra-ocular lens and method of its production|
    GB2217869A|1988-04-22|1989-11-01|Ceskoslovenska Akademie Ved|Contact lenses|
    US5418295A|1989-10-13|1995-05-23|Biocompatibles Limited|Method of reducing protein deposition in sight correction devices|
    US5876438A|1993-08-02|1999-03-02|Houston Biotechnology Incorporated|Polymeric device for the delivery of immunotoxins for the prevention of secondary cataract|
    IL110099D0|1993-07-22|1994-10-07|Johnson & Johnson Vision Prod|Anti-bacterial, insoluble, metal-chelating polymers|
    US5447650A|1993-10-06|1995-09-05|Allergan, Inc.|Composition for preventing the accumulation of inorganic deposits on contact lenses|
    US7468398B2|1994-09-06|2008-12-23|Ciba Vision Corporation|Extended wear ophthalmic lens|
    US5760100B1|1994-09-06|2000-11-14|Ciba Vision Corp|Extended wear ophthalmic lens|
    US6063116A|1994-10-26|2000-05-16|Medarex, Inc.|Modulation of cell proliferation and wound healing|
    DE69629230D1|1995-03-24|2003-09-04|Ocular Res Of Bonton Inc|Hydrogel lens with lipid pre-coating|
    US5770637A|1996-05-01|1998-06-23|Johnson & Johnson Vision Products, Inc.|Anti-bacterial, UV absorbable, tinted, metal-chelating polymers|
    US20040208983A1|2003-04-16|2004-10-21|Hill Gregory A.|Antimicrobial coatings for ophthalmic devices|
    US7118213B2|2004-06-01|2006-10-10|Johnson & Johnson Vision Care, Inc.|Promotional aid|
    JP2009057518A|2007-09-03|2009-03-19|Institute Of Physical & Chemical Research|Anisotropic film and manufacturing method of it|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US05/674,448|US4097657A|1976-04-07|1976-04-07|Surface-treated soft contact lenses|
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